[Prostaglandins and leukotrienes].

The Role of Leukotrienes in Respiratory Tract and Asthma

Polyunsaturated fatty acids play a role as precursors of biolo­gically active compounds that can act as mediators or modulators  of various cell functions. Thus three main groups of derivatives­ the prostaglandins, the thromboxanes, and recently discovered  leukotrienes are formed by oxygenation and further transformation of various polyunsaturated fatty acids of which arachidonic acid  plays t...

The effects of dietary intake of essential fatty acids on prostaglandin and leukotriene synthesis

During the last 25 years prostaglandins and, more recently, leukotrienes have commanded increasing interest in the field of medical research. The identification of these substances as potent local hormones which contribute to many physiological and pathological processes has made them the target for potential new therapies. An understanding of the origin of prostaglandins and leukotrienes has l...

The emerging role of omega-3 fatty acids in psychiatry.

15-HETE is the main eicosanoid present in mucus of ulcerative proctocolitis.

Prostaglandins, leukotrienes and mono-hydroxy acid products of arachidonic acid were measured in mucus of freshly recovered morning stools of a patient with an exacerbation of ulcerative proctocolitis. Eicosanoids in ether extracts were separated by high performance liquid chromatography and amounts determined by radioimmunoassay. Four hydroxy-eicosatetraenoic acids were detected, of which the ...

Prostaglandins and leukotrienes: advances in eicosanoid biology.

Prostaglandins and leukotrienes are potent eicosanoid lipid mediators derived from phospholipase-released arachidonic acid that are involved in numerous homeostatic biological functions and inflammation. They are generated by cyclooxygenase isozymes and 5-lipoxygenase, respectively, and their biosynthesis and actions are blocked by clinically relevant nonsteroidal anti-inflammatory drugs, the n...

Caring for the Critically Ill Patient

EARLY ACUTE LUNG INJURY (ALI) IS characterizedbyneutrophiliclung inflammation,permeability,and intravascular and alveolar fibrin deposition. The proinflammatory and prothrombotic fatty acid eicosanoid derivatives of cyclooxygenase (eg, thromboxaneA2)and5-lipoxygenase(eg,leukotrieneB4)enzymesaremediatorsof these processes. The type and inflammatory activity of eicosanoids liberated during inflam...